mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

mTOR kinase inhibitors block mTORC1 and mTORC2 and thus do not cause the mTORC2 activation of AKT observed with rapamycin. We now show, however, that these drugs have a biphasic effect on AKT. Inhibition of mTORC2 leads to AKT S473 dephosphorylation and a rapid but transient inhibition of AKT T308 p...

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Hauptverfasser: Rodrik-Outmezguine, Vanessa S., Chandarlapaty, Sarat, Pagano, Nen C., Poulikakos, Poulikos I., Scaltriti, Maurizio, Moskatel, Elizabeth, Baselga, José, Guichard, Sylvie, Rosen, Neal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227125/
https://ncbi.nlm.nih.gov/pubmed/22140653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0085
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