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Proarrhythmic defects in Timothy Syndrome require calmodulin kinase II
BACKGROUND: Timothy Syndrome (TS) is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias due to a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). The TS mutation causes loss of normal voltage-dependent inactivation (VDI) of Ca(V)1.2 current (I(Ca)). During...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226825/ https://ncbi.nlm.nih.gov/pubmed/19001023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.788067 |
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