Calmodulin kinase II is required for fight or flight sinoatrial node physiology

The best understood “fight or flight” mechanism for increasing heart rate (HR) involves activation of a cyclic nucleotide-gated ion channel (HCN4) by β-adrenergic receptor (βAR) agonist stimulation. HCN4 conducts an inward “pacemaker” current (I(f)) that increases the sinoatrial nodal (SAN) cell mem...

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Autori principali: Wu, Yuejin, Gao, Zhan, Chen, Biyi, Koval, Olha M., Singh, Madhu V., Guan, Xiaoqun, Hund, Thomas J., Kutschke, William, Sarma, Satyam, Grumbach, Isabella M., Wehrens, Xander H. T., Mohler, Peter J., Song, Long-Sheng, Anderson, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667018/
https://ncbi.nlm.nih.gov/pubmed/19276108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806422106
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