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Genetic Inhibition of Na(+)-Ca(2+) Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate
RATIONALE: The sodium-calcium exchanger 1 (NCX1) is predominantly expressed in the heart and is implicated in controlling automaticity in isolated sinoatrial nodal (SAN) pacemaker cells, but the potential role of NCX1 in determining heart rate in vivo is unknown. OBJECTIVE: Determine the role of Ncx...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562595/ https://ncbi.nlm.nih.gov/pubmed/23192947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300193 |
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