Genetic Inhibition of Na(+)-Ca(2+) Exchanger Current Disables Fight or Flight Sinoatrial Node Activity Without Affecting Resting Heart Rate

RATIONALE: The sodium-calcium exchanger 1 (NCX1) is predominantly expressed in the heart and is implicated in controlling automaticity in isolated sinoatrial nodal (SAN) pacemaker cells, but the potential role of NCX1 in determining heart rate in vivo is unknown. OBJECTIVE: Determine the role of Ncx...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Gao, Zhan, Rasmussen, Tyler P, Li, Yue, Kutschke, William, Koval, Olha M, Wu, Yiming, Wu, Yuejin, Hall, Duane D, Joiner, Mei-ling A, Wu, Xiang-Qiong, Swaminathan, Paari D, Purohit, Anil, Zimmerman, Kathy, Weiss, Robert M, Philipson, Kenneth D, Song, Long-sheng, Hund, Thomas J, Anderson, Mark E
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562595/
https://ncbi.nlm.nih.gov/pubmed/23192947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300193
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados