Inhibition of c-Src Tyrosine Kinase Prevents Angiotensin II-Mediated Connexin43 Remodeling and Sudden Cardiac Death

OBJECTIVES: We sought to test whether c-Src tyrosine kinase mediates connexin 43 (Cx43) reduction and sudden cardiac death in a transgenic mouse model of cardiac-restricted overexpression of angiotensin-converting enzyme (ACE8/8). BACKGROUND: Renin-angiotensin system (RAS) activation is associated w...

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Hlavní autoři: Sovari, Ali A., Iravanian, Shahriar, Dolmatova, Elena, Jiao, Zhe, Liu, Hong, Zandieh, Shadi, Kumar, Vibhash, Wang, Kun, Bernstein, Kenneth E., Bonini, Marcelo G., Duffy, Heather, Dudley, Samuel C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226807/
https://ncbi.nlm.nih.gov/pubmed/22093512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2011.07.048
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