Extracellular signal regulated kinase and GEF-H1 mediate depolarization-induced Rho activation and paracellular permeability increase

Plasma membrane depolarization activates the Rho/Rho kinase (ROK) pathway and thereby enhances myosin light chain (MLC) phosphorylation, which in turn is thought to be a key regulator of paracellular permeability. However, the upstream mechanisms that couple depolarization to Rho activation and perm...

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Bibliographic Details
Main Authors: Waheed, Faiza, Speight, Pam, Kawai, Glenn, Dan, Qinghong, Kapus, András, Szászi, Katalin
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226803/
https://ncbi.nlm.nih.gov/pubmed/20237148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00408.2009
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