Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function

Autism spectrum disorders such as Rett syndrome (RTT) have been hypothesized to arise from defects in experience-dependent synapse maturation. RTT is caused by mutations in MECP2, a nuclear protein that becomes phosphorylated at S421 in response to neuronal activation. We show here that disruption o...

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Autors principals: Cohen, Sonia, Gabel, Harrison W., Hemberg, Martin, Hutchinson, Ashley N., Sadacca, L. Amanda, Ebert, Daniel H., Harmin, David A., Greenberg, Rachel S., Verdine, Vanessa K., Zhou, Zhaolan, Wetsel, William C., West, Anne E., Greenberg, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226708/
https://ncbi.nlm.nih.gov/pubmed/21982370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.08.022
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