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MeCP2 Phosphorylation Limits Psychostimulant-Induced Behavioral and Neuronal Plasticity

The methyl-DNA binding protein MeCP2 is emerging as an important regulator of drug reinforcement processes. Psychostimulants induce phosphorylation of MeCP2 at Ser421; however, the functional significance of this posttranslational modification for addictive-like behaviors was unknown. Here we show t...

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Bibliografiske detaljer
Main Authors: Deng, Jie V., Wan, Yehong, Wang, Xiaoting, Cohen, Sonia, Wetsel, William C., Greenberg, Michael E., Kenny, Paul J., Calakos, Nicole, West, Anne E.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965780/
https://ncbi.nlm.nih.gov/pubmed/24671997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2821-13.2014
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