Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

BACKGROUND: Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit...

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Main Authors: McCann, Christopher K., Growdon, Whitfield B., Kulkarni-Datar, Kashmira, Curley, Michael D., Friel, Anne M., Proctor, Jennifer L., Sheikh, Hana, Deyneko, Igor, Ferguson, Jeanne A., Vathipadiekal, Vinod, Birrer, Michael J., Borger, Darrell R., Mohapatra, Gayatry, Zukerberg, Lawrence R., Foster, Rosemary, MacDougall, John R., Rueda, Bo R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226669/
https://ncbi.nlm.nih.gov/pubmed/22140510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028077
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