Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.

Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis of several cancers including medulloblastoma, basal cell, small cell lung, pancreatic, prostate and ovarian. This investigation was designed to determine if inhibition of this pathway could inhibit serous ovar...

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Detalhes bibliográficos
Main Authors: Christopher K McCann, Whitfield B Growdon, Kashmira Kulkarni-Datar, Michael D Curley, Anne M Friel, Jennifer L Proctor, Hana Sheikh, Igor Deyneko, Jeanne A Ferguson, Vinod Vathipadiekal, Michael J Birrer, Darrell R Borger, Gayatry Mohapatra, Lawrence R Zukerberg, Rosemary Foster, John R Macdougall, Bo R Rueda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3226669?pdf=render
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