Reversal of Isoflurane-Induced Depression of Myocardial Contraction by Nitroxyl via Myofilament Sensitization to Ca(2+)

Isoflurane (ISO) is known to depress cardiac contraction. Here, we hypothesized that decreasing myofilament Ca(2+) responsiveness is central to ISO-induced reduction in cardiac force development. Moreover, we also tested whether the nitroxyl (HNO) donor 1-nitrosocyclohexyl acetate (NCA), acting as a...

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Bibliographic Details
Main Authors: Ding, Wengang, Li, Zhitao, Shen, Xiaoxu, Martin, Jackie, King, S. Bruce, Sivakumaran, Vidhya, Paolocci, Nazareno, Gao, Wei Dong
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226367/
https://ncbi.nlm.nih.gov/pubmed/21865439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185272
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