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Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer
Rheb is a small GTPase primarily known for activating mammalian target of rapamycin complex 1 (mTORC1) and promoting cell growth in response to insulin and nutrients (amino acids, glucose). Shortage of glucose activates adenosine 5′-monophosphate-activated protein kinase (AMPK), which induces catabo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225910/ https://ncbi.nlm.nih.gov/pubmed/22145093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.4.16703 |
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