Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer

Rheb is a small GTPase primarily known for activating mammalian target of rapamycin complex 1 (mTORC1) and promoting cell growth in response to insulin and nutrients (amino acids, glucose). Shortage of glucose activates adenosine 5′-monophosphate-activated protein kinase (AMPK), which induces catabo...

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Main Authors: Lacher, Markus D, Pincheira, Roxana J, Castro, Ariel F
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225910/
https://ncbi.nlm.nih.gov/pubmed/22145093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.2.4.16703
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