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Modulation of RNA splicing as a potential treatment for cancer
Close to 90% of human genes are transcribed into pre-mRNA that undergoes alternative splicing, producing multiple mRNAs and proteins from single genes. This process is largely responsible for human proteome diversity, and about half of genetic disease-causing mutations affect splicing. Splice-switch...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225653/ https://ncbi.nlm.nih.gov/pubmed/21637003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/bbug.2.3.15165 |
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