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Modification of HER2 pre-mRNA alternative splicing and its effects on breast cancer cells
The oncogene HER2 is overexpressed in a variety of human tumors, providing a target for anti-cancer molecular therapies. Here we employed a 2’-O-methoxyethyl (MOE) splice switching oligonucleotide, SSO111, to induce skipping of exon 15 in HER2 pre-mRNA, leading to significant downregulation of full-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671679/ https://ncbi.nlm.nih.gov/pubmed/19035464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.24052 |
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