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Structural Basis and Kinetics of Force-Induced Conformational Changes of an αA Domain-Containing Integrin

BACKGROUND: Integrin α(L)β(2) (lymphocyte function-associated antigen, LFA-1) bears force upon binding to its ligand intercellular adhesion molecule 1 (ICAM-1) when a leukocyte adheres to vascular endothelium or an antigen presenting cell (APC) during immune responses. The ligand binding propensity...

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Main Authors: Xiang, Xue, Lee, Cho-yin, Li, Tian, Chen, Wei, Lou, Jizhong, Zhu, Cheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225382/
https://ncbi.nlm.nih.gov/pubmed/22140490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027946
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