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SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

Huntington's disease (HD) is a progressive neurological disorder for which there are no disease-modifying treatments. Transcriptional dysregulation is a major molecular feature of HD, which significantly contributes to disease progression. Therefore, the development of histone deacetylase (HDAC...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mielcarek, Michal, Benn, Caroline L., Franklin, Sophie A., Smith, Donna L., Woodman, Ben, Marks, Paul A., Bates, Gillian P.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2011
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225376/
https://ncbi.nlm.nih.gov/pubmed/22140466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027746
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