SAHA Decreases HDAC 2 and 4 Levels In Vivo and Improves Molecular Phenotypes in the R6/2 Mouse Model of Huntington's Disease

Huntington's disease (HD) is a progressive neurological disorder for which there are no disease-modifying treatments. Transcriptional dysregulation is a major molecular feature of HD, which significantly contributes to disease progression. Therefore, the development of histone deacetylase (HDAC...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Mielcarek, Michal, Benn, Caroline L., Franklin, Sophie A., Smith, Donna L., Woodman, Ben, Marks, Paul A., Bates, Gillian P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225376/
https://ncbi.nlm.nih.gov/pubmed/22140466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027746
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker