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Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren’s syndrome
CD40L and BAFF, members of TNF superfamily, play critical roles in B cell survival and activation, and in the regulation of humoral immunity. We previously reported that the adaptor molecule Act1 functions as a negative regulator of CD40- and BAFF-mediated B cell survival. Here we demonstrated that...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2008
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3225253/ https://ncbi.nlm.nih.gov/pubmed/18624351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200738113 |
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