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Act1, a novel U-box E3 ubiquitin ligase for IL-17R-mediated signalling
Interleukin (IL)-17, a proinflammatory cytokine mainly produced by T-helper-17 (T(H)17) lineage, is required for host defense against bacteria and fungus infection and plays a critical role in the pathogenesis of inflammatory and autoimmune diseases. Act1 is an essential adaptor molecule in IL-17-me...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3182834/ https://ncbi.nlm.nih.gov/pubmed/19825828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000382 |
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