Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjogren’s syndrome

CD40L and BAFF, members of TNF superfamily, play critical roles in B cell survival and activation, and in the regulation of humoral immunity. We previously reported that the adaptor molecule Act1 functions as a negative regulator of CD40- and BAFF-mediated B cell survival. Here we demonstrated that...

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Bibliographische Detailangaben
Hauptverfasser: Qian, Youcun, Giltiay, Natalia, Xiao, Jianhua, Wang, Yue, Qin, Jinzhong, Tian, Jun, Shuhua, Han, Scott, Martin, Carter, Robert, Li, Xiaoxia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225253/
https://ncbi.nlm.nih.gov/pubmed/18624351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200738113
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