Androgen Receptor Gene Expression in Prostate Cancer is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine Specific Demethylase 1

Androgen receptor (AR) is reactivated in castration resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to increased AR expression at low androgen levels in CRPC. Moreover, at increased and...

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Detalhes bibliográficos
Main Authors: Cai, Changmeng, He, Housheng Hansen, Chen, Sen, Coleman, Ilsa, Wang, Hongyun, Fang, Zi, Chen, Shaoyong, Nelson, Peter S., Liu, X. Shirley, Brown, Myles, Balk, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225024/
https://ncbi.nlm.nih.gov/pubmed/22014572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.09.001
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