R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair

BACKGROUND: CDK-inhibitors can diminish transcriptional levels of cell cycle-related cyclins through the inhibition of E2F family members and CDK7 and 9. Cyclin A1, an E2F-independent cyclin, is strongly upregulated under genotoxic conditions and functionally was shown to increase NHEJ activity. Cyc...

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Autors principals: Federico, Mario, Symonds, Catherine E, Bagella, Luigi, Rizzolio, Flavio, Fanale, Daniele, Russo, Antonio, Giordano, Antonio
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224749/
https://ncbi.nlm.nih.gov/pubmed/20684776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-208
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