Degeneration of penicillin production in ethanol-limited chemostat cultivations of Penicillium chrysogenum: A systems biology approach

BACKGROUND: In microbial production of non-catabolic products such as antibiotics a loss of production capacity upon long-term cultivation (for example chemostat), a phenomenon called strain degeneration, is often observed. In this study a systems biology approach, monitoring changes from gene to pr...

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Main Authors: Douma, Rutger D, Batista, Joana M, Touw, Kai M, Kiel, Jan AKW, Krikken, Arjen M, Zhao, Zheng, Veiga, Tânia, Klaassen, Paul, Bovenberg, Roel AL, Daran, Jean-Marc, Heijnen, Joseph J, van Gulik, Walter M
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224390/
https://ncbi.nlm.nih.gov/pubmed/21854586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-132
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