HYDROXYCHLOROQUINE REDUCES BINDING OF ANTIPHOSPHOLIPID ANTIBODIES TO SYNCYTIOTROPHOBLASTS AND RESTORES ANNEXIN A5 EXPRESSION

OBJECTIVES: Antibody-mediated disruption of the annexin A5 (AnxA5) anticoagulant shield has been posited to be a thrombogenic mechanism in the antiphospholipid syndrome. We recently showed that the antimalarial drug, hydroxychloroquine, dissociates antiphospholipid immune complexes and restores AnxA...

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Bibliographische Detailangaben
Hauptverfasser: Wu, Xiao-Xuan, Guller, Seth, Rand, Jacob H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224185/
https://ncbi.nlm.nih.gov/pubmed/21871597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2011.06.064
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