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Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) and, in an animal model of APS, with reduction of experimentally induced thrombosis. Recognition of β2-glycoprotein I (β2GPI) by aPL antibodi...

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Main Authors: Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., Hathcock, James J., Taatjes, Douglas J.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518879/
https://ncbi.nlm.nih.gov/pubmed/18577708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144204
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