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Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) and, in an animal model of APS, with reduction of experimentally induced thrombosis. Recognition of β2-glycoprotein I (β2GPI) by aPL antibodi...

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Autori principali: Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., Hathcock, James J., Taatjes, Douglas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518879/
https://ncbi.nlm.nih.gov/pubmed/18577708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144204
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