Hydroxychloroquine directly reduces the binding of antiphospholipid antibody–β2-glycoprotein I complexes to phospholipid bilayers

Treatment with the antimalarial drug hydroxychloroquine (HCQ) has been associated with reduced risk of thrombosis in the antiphospholipid (aPL) syndrome (APS) and, in an animal model of APS, with reduction of experimentally induced thrombosis. Recognition of β2-glycoprotein I (β2GPI) by aPL antibodi...

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Detalhes bibliográficos
Main Authors: Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Chen, Pojen P., Hathcock, James J., Taatjes, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518879/
https://ncbi.nlm.nih.gov/pubmed/18577708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-144204
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