Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over phospholipid bilayers (PLBs), blocking their availability for coagulation reactions. Antiphospholipid antibodies disrupt AnxA5 binding, thereby accelerating coagulation reactions. This disruption may contribute to thrombosis...

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Autores principales: Rand, Jacob H., Wu, Xiao-Xuan, Quinn, Anthony S., Ashton, Anthony W., Chen, Pojen P., Hathcock, James J., Andree, Harry A. M., Taatjes, Douglas J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844013/
https://ncbi.nlm.nih.gov/pubmed/19965621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-04-213520
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