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Tandem Electrocyclic Ring Opening/Radical Cyclization: Application to the Total Synthesis of Cribrostatin 6

A concise total synthesis ofcribrostatin 6 (1), an antimicrobial and antineoplastic agent,was accomplished using a tandem electrocyclic ring opening/radical cyclization sequence. Specifically, intermediate4 underwent a 4π-electrocyclic ring opening, radical cyclization, and homolytic aromatic substi...

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Detalhes bibliográficos
Main Authors: Knueppel, Daniel, Martin, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224041/
https://ncbi.nlm.nih.gov/pubmed/22125344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.08.064
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