The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(–) stem cell–like breast cancer cells in human tumors

Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display variable sensitivity to therapeutics and may play different roles in progression. We previously characterized 2 cell populations in human breast tumors with distinct properties: CD44(+)CD24(–) cells that have st...

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Detalhes bibliográficos
Main Authors: Marotta, Lauren L.C., Almendro, Vanessa, Marusyk, Andriy, Shipitsin, Michail, Schemme, Janina, Walker, Sarah R., Bloushtain-Qimron, Noga, Kim, Jessica J., Choudhury, Sibgat A., Maruyama, Reo, Wu, Zhenhua, Gönen, Mithat, Mulvey, Laura A., Bessarabova, Marina O., Huh, Sung Jin, Silver, Serena J., Kim, So Young, Park, So Yeon, Lee, Hee Eun, Anderson, Karen S., Richardson, Andrea L., Nikolskaya, Tatiana, Nikolsky, Yuri, Liu, X. Shirley, Root, David E., Hahn, William C., Frank, David A., Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223826/
https://ncbi.nlm.nih.gov/pubmed/21633165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44745
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