Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of β-catenin in prostate cancer

Fatty acid synthase (FASN), a key metabolic enzyme for liponeogenesis highly expressed in several human cancers, displays oncogenic properties such as resistance to apoptosis and induction of proliferation when overexpressed. To date, no mechanism has been identified to explain the oncogenicity of F...

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Main Authors: Fiorentino, Michelangelo, Zadra, Giorgia, Palescandolo, Emanuele, Fedele, Giuseppe, Bailey, Dyane, Fiore, Christopher, Nguyen, Paul L., Migita, Toshiro, Zamponi, Raffaella, Di Vizio, Dolores, Priolo, Carmen, Chandan, Sharma, Xie, Wanling, Hemler, Martin E., Mucci, Lorelei, Giovannucci, Edward, Finn, Stephen, Loda, Massimo
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223737/
https://ncbi.nlm.nih.gov/pubmed/18838960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2008.97
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