Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time

In laboratory studies, acquired resistance to long-term antihormonal therapy in breast cancer evolves through two phases over 5 y. Phase I develops within 1 y, and tumor growth occurs with either 17β-estradiol (E(2)) or tamoxifen. Phase II resistance develops after 5 y of therapy, and tamoxifen stil...

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Autori principali: Ariazi, Eric A., Cunliffe, Heather E., Lewis-Wambi, Joan S., Slifker, Michael J., Willis, Amanda L., Ramos, Pilar, Tapia, Coya, Kim, Helen R., Yerrum, Smitha, Sharma, Catherine G. N., Nicolas, Emmanuelle, Balagurunathan, Yoganand, Ross, Eric A., Jordan, V. Craig
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223472/
https://ncbi.nlm.nih.gov/pubmed/22011582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115188108
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