Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death

Hypoxic-ischemic (H-I) injury to the developing brain is a significant cause of morbidity and mortality in humans. Other than hypothermia, there is no effective treatment to prevent or lessen the consequences of neonatal H-I. Increased expression of the NAD synthesizing enzyme nicotinamide mononucle...

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Detalhes bibliográficos
Main Authors: Verghese, Philip B., Sasaki, Yo, Yang, Donghan, Stewart, Floy, Sabar, Fatima, Finn, Mary Beth, Wroge, Christine M., Mennerick, Steven, Neil, Jeffrey J., Milbrandt, Jeffrey, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223466/
https://ncbi.nlm.nih.gov/pubmed/22058226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107325108
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