The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Although reduction in leukocyte counts following hydroxyurea therapy in sickle cell disease (SCD) predicts fetal hemoglobin (HbF) response, the underlying mechanism remains unknown. We previously reported that leukocyte counts are regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF...

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Autores principales: Ikuta, Tohru, Adekile, Adekunle D., Gutsaeva, Diana R., Parkerson, James B., Yerigenahally, Shobha D., Clair, Betsy, Kutlar, Abdullah, Odo, Nadine, Head, C. Alvin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223356/
https://ncbi.nlm.nih.gov/pubmed/21945571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2011.08.005
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