The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Although reduction in leukocyte counts following hydroxyurea therapy in sickle cell disease (SCD) predicts fetal hemoglobin (HbF) response, the underlying mechanism remains unknown. We previously reported that leukocyte counts are regulated by granulocyte-macrophage colony-stimulating factor (GM-CSF...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Ikuta, Tohru, Adekile, Adekunle D., Gutsaeva, Diana R., Parkerson, James B., Yerigenahally, Shobha D., Clair, Betsy, Kutlar, Abdullah, Odo, Nadine, Head, C. Alvin
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223356/
https://ncbi.nlm.nih.gov/pubmed/21945571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2011.08.005
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars