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Age-Dependent Susceptibility of Chromosome Cohesion to Premature Separase Activation in Mouse Oocytes

A hypothesis to explain the maternal age-dependent increase in formation of aneuploid eggs is deterioration of chromosome cohesion. Although several lines of evidence are consistent with this hypothesis, whether cohesion is actually reduced in naturally aged oocytes has not been directly tested by a...

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書目詳細資料
Main Authors: Chiang, Teresa, Schultz, Richard M., Lampson, Michael A.
格式: Artigo
語言:Inglês
出版: Society for the Study of Reproduction, Inc. 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223255/
https://ncbi.nlm.nih.gov/pubmed/21865557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.111.094094
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