Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts

Achieving effective treatment outcomes for patients with glioblastoma (GBM) has been impeded by many obstacles, including the pharmacokinetic limitations of antitumor agents, such as topotecan (TPT). Here, we demonstrate that intravenous administration of a novel nanoliposomal formulation of TPT (nL...

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Detalles Bibliográficos
Main Authors: Serwer, Laura P., Noble, Charles O., Michaud, Karine, Drummond, Daryl C., Kirpotin, Dmitri B., Ozawa, Tomoko, Prados, Michael D., Park, John W., James, C. David
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223095/
https://ncbi.nlm.nih.gov/pubmed/21954443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor139
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