Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts

Achieving effective treatment outcomes for patients with glioblastoma (GBM) has been impeded by many obstacles, including the pharmacokinetic limitations of antitumor agents, such as topotecan (TPT). Here, we demonstrate that intravenous administration of a novel nanoliposomal formulation of TPT (nL...

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Bibliographic Details
Main Authors: Serwer, Laura P., Noble, Charles O., Michaud, Karine, Drummond, Daryl C., Kirpotin, Dmitri B., Ozawa, Tomoko, Prados, Michael D., Park, John W., James, C. David
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223095/
https://ncbi.nlm.nih.gov/pubmed/21954443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor139
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