Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma

This open-label, single-arm, phase II study combined enzastaurin with temozolomide plus radiation therapy (RT) to treat glioblastoma multiforme (GBM) and gliosarcoma. Adults with newly diagnosed disease and Karnofsky performance status (KPS) ≥ 60 were enrolled. Treatment was started within 5 weeks a...

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Detalhes bibliográficos
Main Authors: Butowski, Nicholas, Chang, Susan M., Lamborn, Kathleen R., Polley, Mei–Yin, Pieper, Russell, Costello, Joseph F., Vandenberg, Scott, Parvataneni, Rupa, Nicole, Angelina, Sneed, Patricia K., Clarke, Jennifer, Hsieh, Emily, Costa, Bruno M., Reis, Rui M., Hristova-Kazmierski, Maria, Nicol, Steven J., Thornton, Donald E., Prados, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223090/
https://ncbi.nlm.nih.gov/pubmed/21896554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor130
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