rRNA Pseudouridylation Defects Affect Ribosomal Ligand Binding and Translational Fidelity from Yeast to Human Cells

How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthase, DKC1, is mutated in X-linked Dyskeratosis Congenita (X-DC) and Hoyeraal-Hreidarsson syndrome (HH). He...

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Auteurs principaux: Jack, Karen, Bellodi, Cristian, Landry, Dori M., Niederer, Rachel, Meskauskas, Arturas, Musalgaonkar, Sharmishtha, Kopmar, Noam, Krasnykh, Olya, Dean, Alison M., Thompson, Sunnie R., Ruggero, Davide, Dinman, Jonathan D.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222873/
https://ncbi.nlm.nih.gov/pubmed/22099312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.09.017
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