Capsid-specific T-cell Responses to Natural Infections With Adeno-associated Viruses in Humans Differ From Those of Nonhuman Primates

Hepatic adeno-associated virus serotype 2 (AAV2)-mediated gene transfer failed to achieve sustained transgene product expression in human subjects. We formulated the hypothesis that rejection of AAV-transduced hepatocytes is caused by AAV capsid-specific CD8(+) T cells that become reactivated upon g...

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Detalhes bibliográficos
Main Authors: Li, Hua, Lasaro, Marcio O, Jia, Bei, Lin, Shih Wen, Haut, Larissa H, High, Katherine A, Ertl, Hildegund CJ
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222540/
https://ncbi.nlm.nih.gov/pubmed/21587208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.81
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