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RNA Interference Improves Myopathic Phenotypes in Mice Over-expressing FSHD Region Gene 1 (FRG1)

Muscular dystrophies, and other diseases of muscle, arise from recessive and dominant gene mutations. Gene replacement strategies may be beneficial for the former, while gene silencing approaches may provide treatment for the latter. In the last two decades, muscle-directed gene therapies were prima...

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Autors principals: Wallace, Lindsay M, Garwick-Coppens, Sara E, Tupler, Rossella, Harper, Scott Q
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222519/
https://ncbi.nlm.nih.gov/pubmed/21730972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.118
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