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Glutamate transporter (GLT-1) activation enhances nicotine antinociception and attenuates nicotine analgesic tolerance

Analgesic tolerance is partially mediated by enhanced glutamatergic transmission in the CNS. Beta lactam antibiotics, through glutamate transporter subtype 1 (GLT-1) activation, reduce extracellular glutamate levels and attenuate tolerance to morphine analgesia in rats. Like opioids, nicotine has po...

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Detalhes bibliográficos
Main Authors: Schroeder, Joseph A., Quick, Katrina F., Landry, Paige M., Rawls, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222096/
https://ncbi.nlm.nih.gov/pubmed/22027514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0b013e32834d87eb
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