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Glutamate transporter (GLT-1) activation enhances nicotine antinociception and attenuates nicotine analgesic tolerance
Analgesic tolerance is partially mediated by enhanced glutamatergic transmission in the CNS. Beta lactam antibiotics, through glutamate transporter subtype 1 (GLT-1) activation, reduce extracellular glutamate levels and attenuate tolerance to morphine analgesia in rats. Like opioids, nicotine has po...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3222096/ https://ncbi.nlm.nih.gov/pubmed/22027514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0b013e32834d87eb |
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