Treatment with imatinib results in reduced IL-4–producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis

T cells, particularly those producing IL-4, are implicated in inflammation-mediated fibrosis. In our phase I/IIa open-label pilot study in 15 patients with scleroderma-interstitial lung disease (SSc-ILD), high-dose imatinib treatment showed modest improvement in lung function and skin score, but wit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Divekar, Anagha A., Khanna, Dinesh, Abtin, Fereidoun, Maranian, Paul, Saggar, Rajeev, Saggar, Rajan, Furst, Daniel E., Singh, Ram Raj
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221795/
https://ncbi.nlm.nih.gov/pubmed/22015344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.08.010
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge