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Treatment with imatinib results in reduced IL-4–producing T cells, but increased CD4(+) T cells in the broncho-alveolar lavage of patients with systemic sclerosis

T cells, particularly those producing IL-4, are implicated in inflammation-mediated fibrosis. In our phase I/IIa open-label pilot study in 15 patients with scleroderma-interstitial lung disease (SSc-ILD), high-dose imatinib treatment showed modest improvement in lung function and skin score, but wit...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Divekar, Anagha A., Khanna, Dinesh, Abtin, Fereidoun, Maranian, Paul, Saggar, Rajeev, Saggar, Rajan, Furst, Daniel E., Singh, Ram Raj
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221795/
https://ncbi.nlm.nih.gov/pubmed/22015344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2011.08.010
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