Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

Genetic disorders of homocysteine (Hcy) or folate metabolism or high-methionine diets elevate plasma Hcy and its atherogenic metabolite Hcy-thiolactone. In humans, severe hyperhomocysteinemia due to genetic alterations in cystathionine β-synthase (Cbs) or methylenetetrahydrofolate reductase (Mthfr)...

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Autors principals: Jakubowski, Hieronim, Perła-Kaján, Joanna, Finnell, Richard H., Cabrera, Robert M., Wang, Hong, Gupta, Sapna, Kruger, Warren D., Kraus, Jan P., Shih, Diana M.
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2009
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221610/
https://ncbi.nlm.nih.gov/pubmed/19204075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-127548
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