Involvement of the first transmembrane segment of human α(2)-adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine

BACKGROUND AND PURPOSE: Some large antagonist ligands (ARC239, chlorpromazine, prazosin, spiperone, spiroxatrine) bind to the human α(2A)-adrenoceptor with 10- to 100-fold lower affinity than to the α(2B)- and α(2C)-adrenoceptor subtypes. Previous mutagenesis studies have not explained this subtype...

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Bibliographische Detailangaben
Hauptverfasser: Laurila, JMM, Wissel, G, Xhaard, H, Ruuskanen, JO, Johnson, MS, Scheinin, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2011
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221108/
https://ncbi.nlm.nih.gov/pubmed/21649638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01520.x
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