Involvement of the first transmembrane segment of human α(2)-adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine

BACKGROUND AND PURPOSE: Some large antagonist ligands (ARC239, chlorpromazine, prazosin, spiperone, spiroxatrine) bind to the human α(2A)-adrenoceptor with 10- to 100-fold lower affinity than to the α(2B)- and α(2C)-adrenoceptor subtypes. Previous mutagenesis studies have not explained this subtype...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Laurila, JMM, Wissel, G, Xhaard, H, Ruuskanen, JO, Johnson, MS, Scheinin, M
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221108/
https://ncbi.nlm.nih.gov/pubmed/21649638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01520.x
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares