The second extracellular loop of α(2A)-adrenoceptors contributes to the binding of yohimbine analogues

BACKGROUND AND PURPOSE: Rodent α(2A)-adrenoceptors bind the classical α(2)-antagonists yohimbine and rauwolscine with lower affinity than the human α(2A)-adrenoceptor. A serine-cysteine difference in the fifth transmembrane helix (TM; position 5.43) partially explains this, but all determinants of t...

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Autors principals: Laurila, J M M, Xhaard, H, Ruuskanen, J O, Rantanen, M J M, Karlsson, H K, Johnson, M S, Scheinin, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189838/
https://ncbi.nlm.nih.gov/pubmed/17558432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707330
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