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The second extracellular loop of α(2A)-adrenoceptors contributes to the binding of yohimbine analogues
BACKGROUND AND PURPOSE: Rodent α(2A)-adrenoceptors bind the classical α(2)-antagonists yohimbine and rauwolscine with lower affinity than the human α(2A)-adrenoceptor. A serine-cysteine difference in the fifth transmembrane helix (TM; position 5.43) partially explains this, but all determinants of t...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189838/ https://ncbi.nlm.nih.gov/pubmed/17558432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707330 |
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