A Chemical Genomic Analysis of Decoquinate, a Plasmodium falciparum Cytochrome b Inhibitor

[Image: see text] Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro evolution of decoquinate-resistant parasites and subsequent comparative genomic analysis to the drug-sensitive parental strai...

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Détails bibliographiques
Auteurs principaux: Nam, Tae-gyu, McNamara, Case W., Bopp, Selina, Dharia, Neekesh V., Meister, Stephan, Bonamy, Ghislain M. C., Plouffe, David M., Kato, Nobutaka, McCormack, Susan, Bursulaya, Badry, Ke, Hangjun, Vaidya, Akhil B., Schultz, Peter G., Winzeler, Elizabeth A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2011
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220786/
https://ncbi.nlm.nih.gov/pubmed/21866942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200105d
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