Osteopontin Signals through Calcium and Nuclear Factor of Activated T Cells (NFAT) in Osteoclasts: A NOVEL RGD-DEPENDENT PATHWAY PROMOTING CELL SURVIVAL

Osteopontin (OPN), an integrin-binding extracellular matrix glycoprotein, enhances osteoclast activity; however, its mechanisms of action are elusive. The Ca(2+)-dependent transcription factor NFATc1 is essential for osteoclast differentiation. We assessed the effects of OPN on NFATc1, which translo...

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Detalhes bibliográficos
Main Authors: Tanabe, Natsuko, Wheal, Benjamin D., Kwon, Jiyun, Chen, Hong H., Shugg, Ryan P. P., Sims, Stephen M., Goldberg, Harvey A., Dixon, S. Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220590/
https://ncbi.nlm.nih.gov/pubmed/21940634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295048
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