Abrogation of Complex Glycosylation by Swainsonine Results in Strain- and Cell-specific Inhibition of Prion Replication

Neuroblastoma-derived N2a-PK1 cells, fibroblastic LD9 cells, and CNS-derived CAD5 cells can be infected efficiently and persistently by various prion strains, as measured by the standard scrapie cell assay. Swainsonine, an inhibitor of Golgi α-mannosidase II that causes abnormal N-glycosylation, str...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Browning, Shawn, Baker, Christopher A., Smith, Emery, Mahal, Sukhvir P., Herva, Maria E., Demczyk, Cheryl A., Li, Jiali, Weissmann, Charles
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220511/
https://ncbi.nlm.nih.gov/pubmed/21930694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283978
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker